Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment

Targeting specific protein–protein interactions (PPIs) is an attractive concept for drug development, but hard to implement since intracellular antibodies do not penetrate cells and most small-molecule drugs are considered unsuitable for PPI inhibition. A potential solution to these problems is to s...

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Detalles Bibliográficos
Autores principales: Quevedo, Camilo E., Cruz-Migoni, Abimael, Bery, Nicolas, Miller, Ami, Tanaka, Tomoyuki, Petch, Donna, Bataille, Carole J. R., Lee, Lydia Y. W., Fallon, Phillip S., Tulmin, Hanna, Ehebauer, Matthias T., Fernandez-Fuentes, Narcis, Russell, Angela J., Carr, Stephen B., Phillips, Simon E. V., Rabbitts, Terence H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085350/
https://www.ncbi.nlm.nih.gov/pubmed/30093669
http://dx.doi.org/10.1038/s41467-018-05707-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085350/
https://www.ncbi.nlm.nih.gov/pubmed/30093669
http://dx.doi.org/10.1038/s41467-018-05707-2

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