Cargando…

A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer

Accumulating evidence points to a significant role of the circadian clock in the regulation of splicing in various organisms, including mammals. Both dysregulated circadian rhythms and aberrant pre-mRNA splicing are frequently implicated in human disease, in particular in cancer. To investigate the...

Descripción completa

Detalles Bibliográficos
Autores principales:	El-Athman, Rukeia, Fuhr, Luise, Relógio, Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085510/ https://www.ncbi.nlm.nih.gov/pubmed/29936137 http://dx.doi.org/10.1016/j.ebiom.2018.06.012

Ejemplares similares

A Computational Analysis of Alternative Splicing across Mammalian Tissues Reveals Circadian and Ultradian Rhythms in Splicing Events
por: El-Athman, Rukeia, et al.
Publicado: (2019)

Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington’s Disease
por: Yalçin, Müge, et al.
Publicado: (2020)

The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer
por: Fuhr, Luise, et al.
Publicado: (2018)

The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity
por: El-Athman, Rukeia, et al.
Publicado: (2017)

The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes
por: Fuhr, Luise, et al.
Publicado: (2019)

Circadian systems biology: When time matters
por: Fuhr, Luise, et al.
Publicado: (2015)

Antiproliferative Effects of Cynara Cardunculus in Colorectal Cancer Cells Are Modulated by the Circadian Clock
por: Fuhr, Luise, et al.
Publicado: (2022)

Assembly of a Comprehensive Regulatory Network for the Mammalian Circadian Clock: A Bioinformatics Approach
por: Lehmann, Robert, et al.
Publicado: (2015)

A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line
por: Genov, Nikolai, et al.
Publicado: (2019)

Transcriptome analysis of clock disrupted cancer cells reveals differential alternative splicing of cancer hallmarks genes
por: Malhan, Deeksha, et al.
Publicado: (2022)

Diurnal variations in the expression of core-clock genes correlate with resting muscle properties and predict fluctuations in exercise performance across the day
por: Basti, Alireza, et al.
Publicado: (2021)

A mathematical model of the circadian clock and drug pharmacology to optimize irinotecan administration timing in colorectal cancer
por: Hesse, Janina, et al.
Publicado: (2021)

The Circadian Clock, the Immune System, and Viral Infections: The Intricate Relationship Between Biological Time and Host-Virus Interaction
por: Mazzoccoli, Gianluigi, et al.
Publicado: (2020)

Sex and age-dependent characterization of the circadian clock as a potential biomarker for physical performance: A prospective study protocol
por: Yalçin, Müge, et al.
Publicado: (2023)

Differential expression of the circadian clock network correlates with tumour progression in gliomas
por: Petkovic, Marina, et al.
Publicado: (2023)

Systematic Analysis of Mouse Genome Reveals Distinct Evolutionary and Functional Properties Among Circadian and Ultradian Genes
por: Castellana, Stefano, et al.
Publicado: (2018)

A Computational Analysis in a Cohort of Parkinson’s Disease Patients and Clock-Modified Colorectal Cancer Cells Reveals Common Expression Alterations in Clock-Regulated Genes
por: Yalçin, Müge, et al.
Publicado: (2021)

Temporal Splicing Switches in Elements of the TNF-Pathway Identified by Computational Analysis of Transcriptome Data for Human Cell Lines
por: Genov, Nikolai, et al.
Publicado: (2019)

Circadian Dysregulation of the TGFβ/SMAD4 Pathway Modulates Metastatic Properties and Cell Fate Decisions in Pancreatic Cancer Cells
por: Li, Yin, et al.
Publicado: (2020)

Tuning the Mammalian Circadian Clock: Robust Synergy of Two Loops
por: Relógio, Angela, et al.
Publicado: (2011)

Molecular characterization of the circadian clock in paediatric leukaemia patients: a prospective study protocol
por: Ludwig, Marius, et al.
Publicado: (2023)

TimeTeller for timing health: The potential of circadian medicine to improve performance, prevent disease and optimize treatment
por: Dose, Benjamin, et al.
Publicado: (2023)

An Optimal Time for Treatment—Predicting Circadian Time by Machine Learning and Mathematical Modelling
por: Hesse, Janina, et al.
Publicado: (2020)

The reciprocal interplay between TNFα and the circadian clock impacts on cell proliferation and migration in Hodgkin lymphoma cells
por: Abreu, Mónica, et al.
Publicado: (2018)

An integrative mathematical model for timing treatment toxicity and Zeitgeber impact in colorectal cancer cells
por: Hesse, Janina, et al.
Publicado: (2023)

Regulation of alternative splicing by the circadian clock and food related cues
por: McGlincy, Nicholas J, et al.
Publicado: (2012)

A role for alternative splicing in circadian control of exocytosis and glucose homeostasis
por: Marcheva, Biliana, et al.
Publicado: (2020)

Core-Clock Genes Regulate Proliferation and Invasion via a Reciprocal Interplay with MACC1 in Colorectal Cancer Cells
por: Basti, Alireza, et al.
Publicado: (2022)

Ras-Mediated Deregulation of the Circadian Clock in Cancer
por: Relógio, Angela, et al.
Publicado: (2014)

Effect of naive and cancer-educated fibroblasts on colon cancer cell circadian growth rhythm
por: Parascandolo, Alessia, et al.
Publicado: (2020)

The skeletal muscle circadian clock regulates titin splicing through RBM20
por: Riley, Lance A, et al.
Publicado: (2022)

Implications of Circadian Rhythm Regulation by microRNAs in Colorectal Cancer
por: Wu, Song, et al.
Publicado: (2016)

Circadian Regulation of Alternative Splicing of Drought-Associated CIPK Genes in Dendrobium catenatum (Orchidaceae)
por: Wan, Xiao, et al.
Publicado: (2019)

Alternative splicing events implicated in carcinogenesis and prognosis of colorectal cancer
por: Liu, Jingwei, et al.
Publicado: (2018)

The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells
por: Liang, Yu-Chih, et al.
Publicado: (2015)

The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma
por: Muys, Bruna R., et al.
Publicado: (2021)

Epithelial splicing regulatory protein 1 and 2 paralogues correlate with splice signatures and favorable outcome in human colorectal cancer
por: Deloria, Abigail J., et al.
Publicado: (2016)

Role of epigenetic factors in the selection of the alternative splicing isoforms of human KRAS in colorectal cancer cell lines
por: Riffo-Campos, Ángela L., et al.
Publicado: (2018)

Striking circadian neuron diversity and cycling of Drosophila alternative splicing
por: Wang, Qingqing, et al.
Publicado: (2018)

Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation
por: Zhou, Xuexia, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_5btjuph6smdsugssg5t6q4mgp9