Cargando…

The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer

An endogenous molecular clockwork drives various cellular pathways including metabolism and the cell cycle. Its dysregulation is able to prompt pathological phenotypes including cancer. Besides dramatic metabolic alterations, cancer cells display severe changes in the clock phenotype with likely con...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fuhr, Luise, El-Athman, Rukeia, Scrima, Rosella, Cela, Olga, Carbone, Annalucia, Knoop, Henning, Li, Yin, Hoffmann, Karen, Laukkanen, Mikko O., Corcione, Francesco, Steuer, Ralf, Meyer, Thomas F., Mazzoccoli, Gianluigi, Capitanio, Nazzareno, Relógio, Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085544/ https://www.ncbi.nlm.nih.gov/pubmed/30005951 http://dx.doi.org/10.1016/j.ebiom.2018.07.002

Ejemplares similares

The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes
por: Fuhr, Luise, et al.
Publicado: (2019)

A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer
por: El-Athman, Rukeia, et al.
Publicado: (2018)

The Circadian Clock, the Immune System, and Viral Infections: The Intricate Relationship Between Biological Time and Host-Virus Interaction
por: Mazzoccoli, Gianluigi, et al.
Publicado: (2020)

A Computational Analysis of Alternative Splicing across Mammalian Tissues Reveals Circadian and Ultradian Rhythms in Splicing Events
por: El-Athman, Rukeia, et al.
Publicado: (2019)

Parkin Mutation Affects Clock Gene-Dependent Energy Metabolism
por: Pacelli, Consiglia, et al.
Publicado: (2019)

Rewiring carbohydrate catabolism differentially affects survival of pancreatic cancer cell lines with diverse metabolic profiles
por: Tataranni, Tiziana, et al.
Publicado: (2017)

The circadian clock circuitry modulates leukemia initiating cell activity in T-cell acute lymphoblastic leukemia
por: Murgo, Emanuele, et al.
Publicado: (2023)

The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity
por: El-Athman, Rukeia, et al.
Publicado: (2017)

The Histone Variant MacroH2A1 Impacts Circadian Gene Expression and Cell Phenotype in an In Vitro Model of Hepatocellular Carcinoma
por: Carbone, Annalucia, et al.
Publicado: (2021)

Targeting Endoplasmic Reticulum and/or Mitochondrial Ca(2+) Fluxes as Therapeutic Strategy for HCV Infection
por: Scrima, Rosella, et al.
Publicado: (2018)

Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington’s Disease
por: Yalçin, Müge, et al.
Publicado: (2020)

Effect of naive and cancer-educated fibroblasts on colon cancer cell circadian growth rhythm
por: Parascandolo, Alessia, et al.
Publicado: (2020)

The reciprocal interplay between TNFα and the circadian clock impacts on cell proliferation and migration in Hodgkin lymphoma cells
por: Abreu, Mónica, et al.
Publicado: (2018)

On the Origin of Hemoglobin Cooperativity under Non-equilibrium Conditions
por: Scrima, Rosella, et al.
Publicado: (2022)

Nandrolone induces a stem cell-like phenotype in human hepatocarcinoma-derived cell line inhibiting mitochondrial respiratory activity
por: Agriesti, Francesca, et al.
Publicado: (2020)

Aryl Hydrocarbon Receptor Role in Co-Ordinating SARS-CoV-2 Entry and Symptomatology: Linking Cytotoxicity Changes in COVID-19 and Cancers; Modulation by Racial Discrimination Stress
por: Anderson, George, et al.
Publicado: (2020)

Tryptophan Metabolites and Aryl Hydrocarbon Receptor in Severe Acute Respiratory Syndrome, Coronavirus-2 (SARS-CoV-2) Pathophysiology
por: Anderson, George, et al.
Publicado: (2021)

Mitochondrial sAC-cAMP-PKA Axis Modulates the ΔΨ(m)-Dependent Control Coefficients of the Respiratory Chain Complexes: Evidence of Respirasome Plasticity
por: Scrima, Rosella, et al.
Publicado: (2023)

Diurnal variations in the expression of core-clock genes correlate with resting muscle properties and predict fluctuations in exercise performance across the day
por: Basti, Alireza, et al.
Publicado: (2021)

Possible Mechanisms of Mercury Toxicity and Cancer Promotion: Involvement of Gap Junction Intercellular Communications and Inflammatory Cytokines
por: Zefferino, Roberto, et al.
Publicado: (2017)

Antiproliferative Effects of Cynara Cardunculus in Colorectal Cancer Cells Are Modulated by the Circadian Clock
por: Fuhr, Luise, et al.
Publicado: (2022)

Dichloroacetate, a selective mitochondria-targeting drug for oral squamous cell carcinoma: a metabolic perspective of treatment
por: Ruggieri, Vitalba, et al.
Publicado: (2014)

Assembly of a Comprehensive Regulatory Network for the Mammalian Circadian Clock: A Bioinformatics Approach
por: Lehmann, Robert, et al.
Publicado: (2015)

Para-hydroxyphenylpyruvate inhibits the pro-inflammatory stimulation of macrophage preventing LPS-mediated nitro-oxidative unbalance and immunometabolic shift
por: Scrima, Rosella, et al.
Publicado: (2017)

Pathogenic DNM1L Variant (1085G>A) Linked to Infantile Progressive Neurological Disorder: Evidence of Maternal Transmission by Germline Mosaicism and Influence of a Contemporary in cis Variant (1535T>C)
por: Piccoli, Claudia, et al.
Publicado: (2021)

Myoglobin expression by alternative transcript in different mesenchymal stem cells compartments
por: Scrima, Rosella, et al.
Publicado: (2022)

A Multi-Layered Study on Harmonic Oscillations in Mammalian Genomics and Proteomics
por: Genov, Nikolai, et al.
Publicado: (2019)

p-Hydroxyphenylpyruvate, an Intermediate of the Phe/Tyr Catabolism, Improves Mitochondrial Oxidative Metabolism under Stressing Conditions and Prolongs Survival in Rats Subjected to Profound Hemorrhagic Shock
por: Cotoia, Antonella, et al.
Publicado: (2014)

The hexokinase “HKDC1” interaction with the mitochondria is essential for liver cancer progression
por: Khan, Md. Wasim, et al.
Publicado: (2022)

HKDC1 Silencing Inhibits Proliferation and Glycolysis of Gastric Cancer Cells
por: Yu, Chen, et al.
Publicado: (2023)

The Relationship between Clock Genes, Sirtuin 1, and Mitochondrial Activity in Head and Neck Squamous Cell Cancer: Effects of Melatonin Treatment
por: Rodríguez-Santana, César, et al.
Publicado: (2023)

Circadian systems biology: When time matters
por: Fuhr, Luise, et al.
Publicado: (2015)

Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity
por: Pusec, Carolina M., et al.
Publicado: (2023)

The Biological Clock: A Pivotal Hub in Non-alcoholic Fatty Liver Disease Pathogenesis
por: Mazzoccoli, Gianluigi, et al.
Publicado: (2018)

A Role for the Biological Clock in Liver Cancer
por: Mazzoccoli, Gianluigi, et al.
Publicado: (2019)

Coordinated Regulatory Variation Associated with Gestational Hyperglycemia Regulates Expression of the Novel Hexokinase HKDC1
por: Guo, Cong, et al.
Publicado: (2015)

HKDC1 upregulation promotes glycolysis and disease progression, and confers chemoresistance onto gastric cancer
por: Wang, Mei‐Qian, et al.
Publicado: (2023)

Ageing and Low-Level Chronic Inflammation: The Role of the Biological Clock
por: Colombini, Barbara, et al.
Publicado: (2022)

Native LDL-induced oxidative stress in human proximal tubular cells: multiple players involved
por: Piccoli, Claudia, et al.
Publicado: (2011)

Regulation of mitochondrial complex III activity and assembly by TRAP1 in cancer cells
por: Matassa, Danilo Swann, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bkdr13mkef3i16s3t6m8hrpb9c