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The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells
BACKGROUND: Oncogenic Notch1 is known to activate the NF-κB pathway in T cell acute lymphoblastic leukemia (T-ALL) and to up-regulate the transcription of Asb2α, a specificity factor for an E3 ubiquitin ligase complex that plays an important role in hematopoietic differentiation. Therefore, we hypot...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085606/ https://www.ncbi.nlm.nih.gov/pubmed/30116272 http://dx.doi.org/10.1186/s11658-018-0102-4 |