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Exploring the biological functional mechanism of the HMGB1/TLR4/MD-2 complex by surface plasmon resonance

BACKGROUND: High Mobility Group Box 1 (HMGB1) was first identified as a nonhistone chromatin-binding protein that functions as a pro-inflammatory cytokine and a Damage-Associated Molecular Pattern molecule when released from necrotic cells or activated leukocytes. HMGB1 consists of two structurally...

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Detalles Bibliográficos
Autores principales: He, Mingzhu, Bianchi, Marco E., Coleman, Tom R., Tracey, Kevin J., Al-Abed, Yousef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085627/
https://www.ncbi.nlm.nih.gov/pubmed/30134799
http://dx.doi.org/10.1186/s10020-018-0023-8