Cargando…

Geniposide Alleviates Isoproterenol-Induced Cardiac Fibrosis Partially via SIRT1 Activation in vivo and in vitro

Objective: Geniposide (GE) is a major component in the fruit of Gardenia jasminoides Ellis. Oxidative stress, endoplasmic reticulum (ER) stress, and canonical Smad3 pathway are implicated in the pathogenesis of cardiac fibrosis. We aim to investigate the protective roles of GE in isoproterenol (ISO)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Ning, Zhou, Heng, Ma, Zhen-Guo, Zhu, Jin-Xiu, Liu, Chen, Song, Peng, Kong, Chun-Yan, Wu, Hai-Ming, Deng, Wei, Tang, Qi-Zhu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086014/ https://www.ncbi.nlm.nih.gov/pubmed/30123131 http://dx.doi.org/10.3389/fphar.2018.00854

Ejemplares similares

Perindopril Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy
por: Zhu, Zhenyu, et al.
Publicado: (2020)

Galangin Attenuates Isoproterenol-Induced Inflammation and Fibrosis in the Cardiac Tissue of Albino Wistar Rats
por: Thangaiyan, Radhiga, et al.
Publicado: (2020)

Geniposide Protects against Obesity-Related Cardiac Injury through AMPKα- and Sirt1-Dependent Mechanisms
por: Ma, Zhen-Guo, et al.
Publicado: (2018)

Geniposide Alleviates Glucocorticoid-Induced Inhibition of Osteogenic Differentiation in MC3T3-E1 Cells by ERK Pathway
por: Xie, Baocheng, et al.
Publicado: (2019)

Selective HDAC8 Inhibition Attenuates Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis via p38 MAPK Pathway
por: Zhao, Tingwei, et al.
Publicado: (2021)

Combined Administration of Vitamin D(3) and Geniposide Is Less Effective than Single Use of Vitamin D(3) or Geniposide in the Treatment of Ulcerative Colitis
por: Lu, Yingyu, et al.
Publicado: (2021)

Geniposide Ameliorates Liver Fibrosis Through Reducing Oxidative Stress and Inflammatory Respose, Inhibiting Apoptosis and Modulating Overall Metabolism
por: Yang, Lu, et al.
Publicado: (2021)

Qi-Li-Qiang-Xin Alleviates Isoproterenol-Induced Myocardial Injury by Inhibiting Excessive Autophagy via Activating AKT/mTOR Pathway
por: Fan, Cailian, et al.
Publicado: (2019)

Inhibition of Sirt2 Alleviates Fibroblasts Activation and Pulmonary Fibrosis via Smad2/3 Pathway
por: Gong, Hui, et al.
Publicado: (2021)

The Mechanism Underlying the Protective Effects of Tannic Acid Against Isoproterenol-Induced Myocardial Fibrosis in Mice
por: Ma, Donglai, et al.
Publicado: (2020)

Metabonomic analysis of abnormal sphingolipid metabolism in rheumatoid arthritis synovial fibroblasts in hypoxia microenvironment and intervention of geniposide
por: Ke, Jiang-Tao, et al.
Publicado: (2022)

Hydrogen (H(2)) Inhibits Isoproterenol-Induced Cardiac Hypertrophy via Antioxidative Pathways
por: Zhang, Yaxing, et al.
Publicado: (2016)

Isoproterenol Increases Left Atrial Fibrosis and Susceptibility to Atrial Fibrillation by Inducing Atrial Ischemic Infarction in Rats
por: Ma, Shiyu, et al.
Publicado: (2020)

Pterostilbene Alleviates Cholestasis by Promoting SIRT1 Activity in Hepatocytes and Macrophages
por: Ma, Chuanrui, et al.
Publicado: (2021)

Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis via regulation of gut microbiota and bile acid signaling in a mouse model in vivo
por: Li, Hongshan, et al.
Publicado: (2023)

Therapeutic Potential of Polyphenols in Cardiac Fibrosis
por: Zhang, Ning, et al.
Publicado: (2018)

Signaling via the Interleukin-10 Receptor Attenuates Cardiac Hypertrophy in Mice During Pressure Overload, but not Isoproterenol Infusion
por: Stafford, Nicholas, et al.
Publicado: (2020)

Phosphocreatine Attenuates Isoproterenol-Induced Cardiac Fibrosis and Cardiomyocyte Apoptosis
por: Dai, Hui, et al.
Publicado: (2019)

Transcriptomic Validation of the Protective Effects of Aqueous Bark Extract of Terminalia arjuna (Roxb.) on Isoproterenol-Induced Cardiac Hypertrophy in Rats
por: Kumar, Gaurav, et al.
Publicado: (2019)

Renal sympathetic denervation alleviates myocardial fibrosis following isoproterenol-induced heart failure
por: Wang, Neng, et al.
Publicado: (2017)

Anti-Inflammatory Effect of Geniposide on Regulating the Functions of Rheumatoid Arthritis Synovial Fibroblasts via Inhibiting Sphingosine-1-Phosphate Receptors1/3 Coupling Gαi/Gαs Conversion
por: Wang, Rong-hui, et al.
Publicado: (2020)

Therapeutic Effect of Ultrasound Combined With Porous Lipid Clioquinol/PLGA Microbubbles on Ferroptosis in HL-1 Cardiac Cell Induced by Isoproterenol Attack
por: Li, Nana, et al.
Publicado: (2022)

Ciprofol attenuates the isoproterenol-induced oxidative damage, inflammatory response and cardiomyocyte apoptosis
por: Yang, Yunzhao, et al.
Publicado: (2022)

Cordyceps cicadae Ameliorates Renal Hypertensive Injury and Fibrosis Through the Regulation of SIRT1-Mediated Autophagy
por: Cai, Yuzi, et al.
Publicado: (2022)

Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis
por: Chen, Yan, et al.
Publicado: (2022)

Sophocarpine Alleviates Isoproterenol-Induced Kidney Injury by Suppressing Inflammation, Apoptosis, Oxidative Stress and Fibrosis
por: Zhou, Wei, et al.
Publicado: (2022)

Metformin Alleviates Steatohepatitis in Diet-Induced Obese Mice in a SIRT1-Dependent Way
por: Guo, Wan-rong, et al.
Publicado: (2021)

Cannabidiol markedly alleviates skin and liver fibrosis
por: del Río, Carmen, et al.
Publicado: (2022)

Geniposide and Chlorogenic Acid Combination Improves Non-Alcoholic Fatty Liver Disease Involving the Potent Suppression of Elevated Hepatic SCD-1
por: Chen, Cheng, et al.
Publicado: (2021)

Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway
por: Liu, Xiaoyu, et al.
Publicado: (2021)

Geniposide Possesses the Protective Effect on Myocardial Injury by Inhibiting Oxidative Stress and Ferroptosis via Activation of the Grsf1/GPx4 Axis
por: Shen, Yuehong, et al.
Publicado: (2022)

Anti-inflammatory Mechanism of Geniposide: Inhibiting the Hyperpermeability of Fibroblast-Like Synoviocytes via the RhoA/p38MAPK/NF-κB/F-Actin Signal Pathway
por: Deng, Ran, et al.
Publicado: (2018)

Geniposide Alleviates Amyloid-Induced Synaptic Injury by Protecting Axonal Mitochondrial Trafficking
por: Zhang, Haijing, et al.
Publicado: (2017)

Verapamil Alleviates Myocardial Ischemia/Reperfusion Injury by Attenuating Oxidative Stress via Activation of SIRT1
por: Bao, Mi, et al.
Publicado: (2022)

Renal Denervation Findings on Cardiac and Renal Fibrosis in Rats with Isoproterenol Induced Cardiomyopathy
por: Liu, Qian, et al.
Publicado: (2015)

Syringic acid mitigates isoproterenol‐induced cardiac hypertrophy and fibrosis by downregulating Ereg
por: Han, Xiongyi, et al.
Publicado: (2022)

Geniposide and Chlorogenic Acid Combination Ameliorates Non-alcoholic Steatohepatitis Involving the Protection on the Gut Barrier Function in Mouse Induced by High-Fat Diet
por: Peng, Jing-hua, et al.
Publicado: (2018)

Trimetazidine Ameliorates Myocardial Metabolic Remodeling in Isoproterenol-Induced Rats Through Regulating Ketone Body Metabolism via Activating AMPK and PPAR α
por: Li, Huihui, et al.
Publicado: (2020)

β-hydroxybutyrate Alleviates Learning and Memory Impairment Through the SIRT1 Pathway in D-Galactose-Injured Mice
por: Yang, Xiaojing, et al.
Publicado: (2021)

The combination of Lonicerae Japonicae Flos and Forsythiae Fructus herb-pair alleviated inflammation in liver fibrosis
por: Zhang, Jing-Bei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2p0blqj1ed3fq4uv1vsho1hmqq