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Defective germline reprogramming rewires the spermatogonial transcriptome
Defective germline reprogramming in Miwi2- and Dnmt3l-deficient mice results in the failure to reestablish transposon silencing, meiotic arrest and progressive loss of spermatogonia. Here we sought to understand the molecular basis for this spermatogonial dysfunction. Through a combination of imagin...
Autores principales: | Vasiliauskaitė, Lina, Berrens, Rebecca V, Ivanova, Ivayla, Carrieri, Claudia, Reik, Wolf, Enright, Anton J, O’Carroll, Dónal |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086329/ https://www.ncbi.nlm.nih.gov/pubmed/29728652 http://dx.doi.org/10.1038/s41594-018-0058-0 |
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