Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading

DNA interstrand crosslinks (ICLs) are extremely cytotoxic, but the mechanism of their repair remains incompletely understood. Using Xenopus egg extracts, we previously showed that repair of a cisplatin ICL is triggered when two replication forks converge on the lesion. After CDC45/MCM2-7/GINS (CMG)...

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Detalles Bibliográficos
Autores principales: Amunugama, Ravindra, Willcox, Smaranda, Wu, R. Alex, Abdullah, Ummi B., El-Sagheer, Afaf H., Brown, Tom, McHugh, Peter J., Griffith, Jack D., Walter, Johannes C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086610/
https://www.ncbi.nlm.nih.gov/pubmed/29924986
http://dx.doi.org/10.1016/j.celrep.2018.05.061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086610/
https://www.ncbi.nlm.nih.gov/pubmed/29924986
http://dx.doi.org/10.1016/j.celrep.2018.05.061

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