Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants

The innate immune sensor retinoic acid-inducible gene I (RIG-I) detects cytosolic viral RNA and requires a conformational change caused by both ATP and RNA binding to induce an active signaling state and to trigger an immune response. Previously, we showed that ATP hydrolysis removes RIG-I from lowe...

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Detalles Bibliográficos
Autores principales: Lässig, Charlotte, Lammens, Katja, Gorenflos López, Jacob Lucián, Michalski, Sebastian, Fettscher, Olga, Hopfner, Karl-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086658/
https://www.ncbi.nlm.nih.gov/pubmed/30047865
http://dx.doi.org/10.7554/eLife.38958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086658/
https://www.ncbi.nlm.nih.gov/pubmed/30047865
http://dx.doi.org/10.7554/eLife.38958

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