Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABA(A) receptor in complex with GABA

Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by GABA(A) receptors, chloride-selective members of the superfamily of pentameric Cys-loop receptors. Native GABA(A) receptors are heteromeric assemblies sensitive to many important drugs, from sedatives to anesthe...

Descripción completa

Detalles Bibliográficos
Autores principales: Phulera, Swastik, Zhu, Hongtao, Yu, Jie, Claxton, Derek P, Yoder, Nate, Yoshioka, Craig, Gouaux, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086659/
https://www.ncbi.nlm.nih.gov/pubmed/30044221
http://dx.doi.org/10.7554/eLife.39383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086659/
https://www.ncbi.nlm.nih.gov/pubmed/30044221
http://dx.doi.org/10.7554/eLife.39383

Ejemplares similares