Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells

ARID1A, a component of the SWI/SNF chromatin remodeling complex, is a tumor suppressor with a high frequency of inactivating mutations in many cancers. Therefore, ARID1A deficiency has been exploited therapeutically for treating cancer. Here we show that ARID1A has a synthetic lethal interaction wit...

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Detalles Bibliográficos
Autores principales: Wu, Changjie, Lyu, Junfang, Yang, Eun Ju, Liu, Yifan, Zhang, Baoyuan, Shim, Joong Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086874/
https://www.ncbi.nlm.nih.gov/pubmed/30097580
http://dx.doi.org/10.1038/s41467-018-05694-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086874/
https://www.ncbi.nlm.nih.gov/pubmed/30097580
http://dx.doi.org/10.1038/s41467-018-05694-4

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