K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression

BACKGROUND: Alzheimer’s disease, which is pathologically characterized by an excessive accumulation of amyloid beta (Aβ) fibrils, is a degenerative brain disease and the most common cause of dementia. In a previous study, it was reported that an increased level of CHI3L1 in plasma was found in AD pa...

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Detalles Bibliográficos
Autores principales: Choi, Ji Yeon, Yeo, In Jun, Kim, Ki Cheon, Choi, Won Rack, Jung, Jae-Kyung, Han, Sang-Bae, Hong, Jin Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087013/
https://www.ncbi.nlm.nih.gov/pubmed/30098604
http://dx.doi.org/10.1186/s12974-018-1269-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087013/
https://www.ncbi.nlm.nih.gov/pubmed/30098604
http://dx.doi.org/10.1186/s12974-018-1269-3

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