Otx2 promotes granule cell precursor proliferation and Shh-dependent medulloblastoma maintenance in vivo

The developmental gene OTX2 is expressed by cerebellar granule cell precursors (GCPs), a cell population which undergoes massive expansion during the early postnatal period in response to sonic hedgehog (Shh). GCPs are thought to be at the origin of most medulloblastomas, a devastating paediatric ca...

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Detalles Bibliográficos
Autores principales: El Nagar, Salsabiel, Chakroun, Almahdi, Le Greneur, Coralie, Figarella-Branger, Dominique, Di Meglio, Thomas, Lamonerie, Thomas, Billon, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087714/
https://www.ncbi.nlm.nih.gov/pubmed/30100614
http://dx.doi.org/10.1038/s41389-018-0070-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087714/
https://www.ncbi.nlm.nih.gov/pubmed/30100614
http://dx.doi.org/10.1038/s41389-018-0070-6

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