Cargando…
Otx2 promotes granule cell precursor proliferation and Shh-dependent medulloblastoma maintenance in vivo
The developmental gene OTX2 is expressed by cerebellar granule cell precursors (GCPs), a cell population which undergoes massive expansion during the early postnatal period in response to sonic hedgehog (Shh). GCPs are thought to be at the origin of most medulloblastomas, a devastating paediatric ca...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087714/ https://www.ncbi.nlm.nih.gov/pubmed/30100614 http://dx.doi.org/10.1038/s41389-018-0070-6 |