Target-Directed Self-Assembly of Homodimeric Drugs Against β-Tryptase

[Image: see text] Tryptase, a serine protease released from mast cells, is implicated in many allergic and inflammatory disorders. Human tryptase is a donut-shaped tetramer with the active sites facing inward forming a central pore. Bivalent ligands spanning two active sites potently inhibit this co...

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Detalles Bibliográficos
Autores principales: Giardina, Sarah F., Werner, Douglas S., Pingle, Maneesh, Foreman, Kenneth W., Bergstrom, Donald E., Arnold, Lee D., Barany, Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088348/
https://www.ncbi.nlm.nih.gov/pubmed/30128075
http://dx.doi.org/10.1021/acsmedchemlett.8b00204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088348/
https://www.ncbi.nlm.nih.gov/pubmed/30128075
http://dx.doi.org/10.1021/acsmedchemlett.8b00204

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