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Target-Directed Self-Assembly of Homodimeric Drugs Against β-Tryptase
[Image: see text] Tryptase, a serine protease released from mast cells, is implicated in many allergic and inflammatory disorders. Human tryptase is a donut-shaped tetramer with the active sites facing inward forming a central pore. Bivalent ligands spanning two active sites potently inhibit this co...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088348/ https://www.ncbi.nlm.nih.gov/pubmed/30128075 http://dx.doi.org/10.1021/acsmedchemlett.8b00204 |