Conformational changes in amyloid-beta (12–28) alloforms studied using action-FRET, IMS and molecular dynamics simulations

Small oligomers of the amyloid beta protein (Aβ) have been implicated as the neurotoxic agent leading to Alzheimer's disease, and in particular mutations in the hydrophobic core region comprising amino acids L17 to A21 have a large influence on the propensity for aggregate formation. It has bee...

Descripción completa

Detalles Bibliográficos
Autores principales: Daly, Steven, Kulesza, Alexander, Poussigue, Frederic, Simon, Anne-Laure, Choi, Chang Min, Knight, Geoffrey, Chirot, Fabien, MacAleese, Luke, Antoine, Rodolphe, Dugourd, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088554/
https://www.ncbi.nlm.nih.gov/pubmed/30155007
http://dx.doi.org/10.1039/c5sc01463h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088554/
https://www.ncbi.nlm.nih.gov/pubmed/30155007
http://dx.doi.org/10.1039/c5sc01463h

Ejemplares similares