Survivin-targeting miR-542-3p overcomes HER3 signaling-induced chemoresistance and enhances the antitumor activity of paclitaxel against HER2-overexpressing breast cancer

Elevated expression of HER3, which interacts with HER2 in breast cancer cells, confers chemoresistance via phosphoinositide 3-kinase (PI-3K)/Akt-dependent upregulation of Survivin. However, the underlying mechanism is not clear. Ectopic expression or specific knockdown of HER3 in HER2-overexpressing...

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Detalles Bibliográficos
Autores principales: Lyu, Hui, Wang, Shuiliang, Huang, Jingcao, Wang, Bolun, He, Zhimin, Liu, Bolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089084/
https://www.ncbi.nlm.nih.gov/pubmed/29409974
http://dx.doi.org/10.1016/j.canlet.2018.01.065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089084/
https://www.ncbi.nlm.nih.gov/pubmed/29409974
http://dx.doi.org/10.1016/j.canlet.2018.01.065

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