ARNT/HIF‐1β links high‐risk 1q21 gain and microenvironmental hypoxia to drug resistance and poor prognosis in multiple myeloma

1q21 gain is a common cytogenetic abnormality featuring high‐risk multiple myeloma (HRMM). However, the molecular mechanism underlying the adverse prognostic effect of 1q21 gain remains largely unclear. Here, we report that ARNT/HIF‐1β, a 1q21 gene, is highly expressed in HRMM and induced by microen...

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Detalles Bibliográficos
Autores principales: Wu, Chuan, Yang, Ting, Liu, Yingmin, Lu, Yicheng, Yang, Yanping, Liu, Xiaobo, Liu, Xuelian, Ye, Long, Sun, Yue, Wang, Xue, Li, Qingchao, Yang, Peiyu, Yu, Xiaoyuan, Gao, Sujun, Kumar, Shaji, Jin, Fengyan, Dai, Yun, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089175/
https://www.ncbi.nlm.nih.gov/pubmed/29926531
http://dx.doi.org/10.1002/cam4.1596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089175/
https://www.ncbi.nlm.nih.gov/pubmed/29926531
http://dx.doi.org/10.1002/cam4.1596

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