Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents

INTRODUCTION: The goal of this study was to examine the effects of selinexor, an inhibitor of exportin-1 mediated nuclear export, on DNA damage repair and to evaluate the cytotoxic effects of selinexor in combination with DNA damaging agents (DDAs) in cancer cells. RESULTS: Selinexor reduced the exp...

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Detalles Bibliográficos
Autores principales: Kashyap, Trinayan, Argueta, Christian, Unger, Thaddeus, Klebanov, Boris, Debler, Sophia, Senapedis, William, Crochiere, Marsha L., Lee, Margaret S., Kauffman, Michael, Shacham, Sharon, Landesman, Yosef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089403/
https://www.ncbi.nlm.nih.gov/pubmed/30112106
http://dx.doi.org/10.18632/oncotarget.25637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089403/
https://www.ncbi.nlm.nih.gov/pubmed/30112106
http://dx.doi.org/10.18632/oncotarget.25637

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