Cargando…

Fasudil preserves lung endothelial function and reduces pulmonary vascular remodeling in a rat model of end-stage pulmonary hypertension with left heart disease

Pulmonary hypertension (PH) due to left heart disease (LHD) is a common condition associated with significant morbidity. It contributes to the elevation of pulmonary vascular resistance and mean pulmonary pressure, eventually leading to heart failure and even mortality. The present study aimed to ex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhuang, Rulin, Wu, Jinfu, Lin, Fang, Han, Lu, Liang, Xiaoting, Meng, Qingshu, Jiang, Yuyu, Wang, Zhulin, Yue, Aixue, Gu, Yuying, Fan, Huimin, Zhou, Xiaohui, Liu, Zhongmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089763/ https://www.ncbi.nlm.nih.gov/pubmed/29901088 http://dx.doi.org/10.3892/ijmm.2018.3728

Ejemplares similares

A novel small molecule compound VCP979 improves ventricular remodeling in murine models of myocardial ischemia/reperfusion injury
por: Liu, Jing, et al.
Publicado: (2020)

Effects of Fasudil on Patients with Pulmonary Hypertension Associated with Left Ventricular Heart Failure with Preserved Ejection Fraction: A Prospective Intervention Study
por: Zhang, Xiang, et al.
Publicado: (2018)

CAR Selectively Enhances the Pulmonary Vasodilatory Effect of Fasudil in a Microsphere Model of Pulmonary Hypertension
por: Rothman, Abraham, et al.
Publicado: (2023)

AFC1 Compound Attenuated MI/R-Induced Ventricular Remodeling via Inhibiting PDGFR and STAT Pathway
por: Liu, Jie, et al.
Publicado: (2019)

Fasudil, a Rho-Kinase Inhibitor, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice
por: Jiang, Chunguo, et al.
Publicado: (2012)

Peptide-Coated Liposomal Fasudil Enhances Site Specific Vasodilation in Pulmonary Arterial Hypertension
por: Nahar, Kamrun, et al.
Publicado: (2014)

CD4(+)FoxP3(+)CD73(+) regulatory T cell promotes cardiac healing post-myocardial infarction
por: Zhuang, Rulin, et al.
Publicado: (2022)

Intravenously Administered Human Umbilical Cord-Derived Mesenchymal Stem Cell (HucMSC) Improves Cardiac Performance following Infarction via Immune Modulation
por: Liang, Xiaoting, et al.
Publicado: (2023)

Resident cell lineages are preserved in pulmonary vascular remodeling
por: Crnkovic, Slaven, et al.
Publicado: (2018)

Fasudil Dichloroacetate Alleviates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension by Ameliorating Dysfunction of Pulmonary Arterial Smooth Muscle Cells
por: Liu, Ping, et al.
Publicado: (2021)

Fasudil, a Rho-kinase inhibitor, prevents intima-media thickening in a partially ligated carotid artery mouse model: Effects of fasudil in flow-induced vascular remodeling
por: Zhang, Xiangyu, et al.
Publicado: (2015)

Distinct Circulating Expression Profiles of Long Noncoding RNAs in Heart Failure Patients With Ischemic and Nonischemic Dilated Cardiomyopathy
por: Lin, Fang, et al.
Publicado: (2019)

Intramyocardial injected human umbilical cord-derived mesenchymal stem cells (HucMSCs) contribute to the recovery of cardiac function and the migration of CD4(+) T cells into the infarcted heart via CCL5/CCR5 signaling
por: Liu, Jing, et al.
Publicado: (2022)

Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study
por: Lan, Qin, et al.
Publicado: (2020)

Therapeutic potentials of fasudil in liver fibrosis
por: Xi, Yue, et al.
Publicado: (2021)

Combination of fasudil and celecoxib promotes the recovery of injured spinal cord in rats better than celecoxib or fasudil alone
por: Hou, Xiao-lin, et al.
Publicado: (2015)

IL-27 promotes cardiac fibroblast activation and aggravates cardiac remodeling post myocardial infarction
por: Ma, Xiaoxue, et al.
Publicado: (2023)

Effects of fasudil on blood–brain barrier integrity
por: Sato, Kei, et al.
Publicado: (2022)

The Rho/Rho-associated protein kinase inhibitor fasudil in the protection of endothelial cells against advanced glycation end products through the nuclear factor κB pathway
por: LU, YUYAN, et al.
Publicado: (2013)

Conditioned medium from induced pluripotent stem cell-derived mesenchymal stem cells accelerates cutaneous wound healing through enhanced angiogenesis
por: Liang, Xiaoting, et al.
Publicado: (2021)

Pulmonary Vascular Remodeling in Pulmonary Hypertension
por: Jia, Zhuangzhuang, et al.
Publicado: (2023)

Dynamic Profile of CD4(+) T-Cell-Associated Cytokines/Chemokines following Murine Myocardial Infarction/Reperfusion
por: Yuan, Dongsheng, et al.
Publicado: (2019)

ROCK inhibitor fasudil reduces the expression of inflammatory factors in LPS-induced rat pulmonary microvascular endothelial cells via ROS/NF-κB pathway
por: Liu, Huanlong, et al.
Publicado: (2022)

High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels
por: Ichinomiya, Taiga, et al.
Publicado: (2012)

Effects of rosuvastatin combined with fasudil therapy on rabbits with dyslipidemia
por: Li, Zhiming, et al.
Publicado: (2015)

Metabolomics study of fasudil on cisplatin-induced kidney injury
por: Xia, Demeng, et al.
Publicado: (2019)

Effect of Fasudil on remyelination following cuprizone‐induced demyelination
por: Wang, Jing, et al.
Publicado: (2019)

Hydrochloride fasudil attenuates brain injury in ICH rats
por: Li, Limin, et al.
Publicado: (2020)

Pulmonary remodeling in asthma
por: Lieberman, Phil
Publicado: (2010)

Myocardial ischemia‐reperfusion induced cardiac extracellular vesicles harbour proinflammatory features and aggravate heart injury
por: Ge, Xinyu, et al.
Publicado: (2021)

Characteristics of circular RNA expression of pulmonary macrophages in mice with sepsis‐induced acute lung injury
por: Bao, Xiaowei, et al.
Publicado: (2019)

Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease
por: Tatenhorst, Lars, et al.
Publicado: (2016)

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil
por: Sellers, Katherine J., et al.
Publicado: (2018)

Effect of fasudil on cognitive function following status convulsion in rats
por: He, Rong, et al.
Publicado: (2017)

Retraction: Effect of Fasudil on remyelination following cuprizone‐induced demyelination.
por: Wang, Jing, et al.
Publicado: (2020)

Effect of fasudil on experimental autoimmune neuritis and its mechanisms of action
por: Zhao, Yanyin, et al.
Publicado: (2019)

Exercise preconditioning prevents left ventricular dysfunction and remodeling in monocrotaline-induced pulmonary hypertension
por: Schmidt, Cristine, et al.
Publicado: (2020)

Sotatercept analog improves cardiopulmonary remodeling and pulmonary hypertension in experimental left heart failure
por: Joshi, Sachindra R., et al.
Publicado: (2023)

Pulmonary Fibroelastotic Remodelling Revisited
por: Braubach, Peter, et al.
Publicado: (2021)

Pulmonary venous remodeling in COPD-pulmonary hypertension and idiopathic pulmonary arterial hypertension
por: Andersen, Kasper Hasseriis, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_pb8kk02i0bm3k8t8blrmi88980