IL-1β and TNF-α suppress TGF-β-promoted NGF expression in periodontal ligament-derived fibroblasts through inactivation of TGF-β-induced Smad2/3- and p38 MAPK-mediated signals

Mechanosensitive (MS) neurons in the periodontal ligament (PDL) pass information to the trigeminal ganglion when excited by mechanical stimulation of the tooth. During occlusal tooth trauma of PDL tissues, MS neurons are injured, resulting in atrophic neurites and eventual degeneration of MS neurons...

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Detalles Bibliográficos
Autores principales: Ohta, Maiko, Chosa, Naoyuki, Kyakumoto, Seiko, Yokota, Seiji, Okubo, Naoto, Nemoto, Akira, Kamo, Masaharu, Joh, Shigeharu, Satoh, Kenichi, Ishisaki, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089780/
https://www.ncbi.nlm.nih.gov/pubmed/29901090
http://dx.doi.org/10.3892/ijmm_2018.3714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089780/
https://www.ncbi.nlm.nih.gov/pubmed/29901090
http://dx.doi.org/10.3892/ijmm_2018.3714

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