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A peptide containing the receptor binding site of insulin-like growth factor binding protein-2 enhances bone mass in ovariectomized rats

Male Igfbp2−/− mice have a significant reduction in bone mass and administration of a peptide that contains the insulin-like growth factor binding protein-2(IGFBP-2) receptor-binding domain stimulates bone formation in these animals. Female Igfbp2−/− mice do not have this phenotype but following ova...

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Detalles Bibliográficos
Autores principales: Xi, Gang, Wai, Christine, Rosen, Clifford J., Clemmons, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089876/
https://www.ncbi.nlm.nih.gov/pubmed/30109160
http://dx.doi.org/10.1038/s41413-018-0024-9