Two novel SHP-1 agonists, SC-43 and SC-78, are more potent than regorafenib in suppressing the in vitro stemness of human colorectal cancer cells

Signal transducer and activator of transcription 3 (STAT3) has been shown to play a critical role in the maintenance of cancer stem cells (CSCs). Hence, the inhibition of STAT3 signaling has been suggested to be a viable therapeutic approach for cancers. Moreover, the efficacy of combinations of che...

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Detalles Bibliográficos
Autores principales: Chung, Shin-Yi, Chen, Yen-Hsi, Lin, Pei-Rong, Chao, Ta-Chung, Su, Jung-Chen, Shiau, Chung-Wai, Su, Yeu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089896/
https://www.ncbi.nlm.nih.gov/pubmed/30109144
http://dx.doi.org/10.1038/s41420-018-0084-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089896/
https://www.ncbi.nlm.nih.gov/pubmed/30109144
http://dx.doi.org/10.1038/s41420-018-0084-z

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