TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway

Human T regulatory cells (T regs) express high levels of TNF receptor 2 (TNFR2). Ligation of TNFR2 with TNF, which can recognise both TNFR1 and TNFR2, or with a TNFR2-selective binding molecule, DARPin 18 (D18) activates canonical NF-κB signalling, assessed by IκBα degradation, and the magnitude of...

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Detalles Bibliográficos
Autores principales: Wang, Jun, Ferreira, Ricardo, Lu, Wanhua, Farrow, Samatha, Downes, Kate, Jermutus, Lutz, Minter, Ralph, Al-Lamki, Rafia S., Pober, Jordan S., Bradley, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089958/
https://www.ncbi.nlm.nih.gov/pubmed/30104686
http://dx.doi.org/10.1038/s41598-018-30621-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089958/
https://www.ncbi.nlm.nih.gov/pubmed/30104686
http://dx.doi.org/10.1038/s41598-018-30621-4

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