Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level

Mechanism-based glycoside hydrolase inhibitors are carbohydrate analogs that mimic the natural substrate’s structure. Their covalent bond formation with the glycoside hydrolase makes these compounds excellent tools for chemical biology and potential drug candidates. Here we report the synthesis of c...

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Detalles Bibliográficos
Autores principales: Ren, Weiwu, Pengelly, Robert, Farren-Dai, Marco, Shamsi Kazem Abadi, Saeideh, Oehler, Verena, Akintola, Oluwafemi, Draper, Jason, Meanwell, Michael, Chakladar, Saswati, Świderek, Katarzyna, Moliner, Vicent, Britton, Robert, Gloster, Tracey M., Bennet, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089974/
https://www.ncbi.nlm.nih.gov/pubmed/30104598
http://dx.doi.org/10.1038/s41467-018-05702-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089974/
https://www.ncbi.nlm.nih.gov/pubmed/30104598
http://dx.doi.org/10.1038/s41467-018-05702-7

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