Itch suppression in mice and dogs by modulation of spinal α2 and α3GABA(A) receptors

Chronic itch is a highly debilitating condition affecting about 10% of the general population. The relay of itch signals is under tight control by inhibitory circuits of the spinal dorsal horn, which may offer a hitherto unexploited therapeutic opportunity. Here, we found that specific pharmacologic...

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Detalles Bibliográficos
Autores principales: Ralvenius, William T., Neumann, Elena, Pagani, Martina, Acuña, Mario A., Wildner, Hendrik, Benke, Dietmar, Fischer, Nina, Rostaher, Ana, Schwager, Simon, Detmar, Michael, Frauenknecht, Katrin, Aguzzi, Adriano, Hubbs, Jed Lee, Rudolph, Uwe, Favrot, Claude, Zeilhofer, Hanns Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089996/
https://www.ncbi.nlm.nih.gov/pubmed/30104684
http://dx.doi.org/10.1038/s41467-018-05709-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089996/
https://www.ncbi.nlm.nih.gov/pubmed/30104684
http://dx.doi.org/10.1038/s41467-018-05709-0

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