Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations

Recent studies have suggested that genes longer than 100 kb are more likely to be misregulated in neurological diseases associated with synaptic dysfunction, such as autism and Rett syndrome. These length-dependent transcriptional changes are modest in MeCP2-mutant samples, but, given the low sensit...

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Detalles Bibliográficos
Autores principales: Raman, Ayush T., Pohodich, Amy E., Wan, Ying-Wooi, Yalamanchili, Hari Krishna, Lowry, William E., Zoghbi, Huda Y., Liu, Zhandong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089998/
https://www.ncbi.nlm.nih.gov/pubmed/30104565
http://dx.doi.org/10.1038/s41467-018-05627-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089998/
https://www.ncbi.nlm.nih.gov/pubmed/30104565
http://dx.doi.org/10.1038/s41467-018-05627-1

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