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Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations
Recent studies have suggested that genes longer than 100 kb are more likely to be misregulated in neurological diseases associated with synaptic dysfunction, such as autism and Rett syndrome. These length-dependent transcriptional changes are modest in MeCP2-mutant samples, but, given the low sensit...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089998/ https://www.ncbi.nlm.nih.gov/pubmed/30104565 http://dx.doi.org/10.1038/s41467-018-05627-1 |