The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats

BACKGROUND: Current antiepileptic drugs are not able to prevent recurrent seizures in all patients. Orexins are excitatory hypothalamic neuropeptides that their receptors (Orx1R and Orx2R) are found almost in all major regions of the brain. Pentylenetetrazol (PTZ)-induced kindling is a known experim...

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Detalles Bibliográficos
Autores principales: Asadi, Saeedeh, Roohbakhsh, Ali, Shamsizadeh, Ali, Fereidoni, Masoud, Kordijaz, Elham, Moghimi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090721/
https://www.ncbi.nlm.nih.gov/pubmed/30103703
http://dx.doi.org/10.1186/s12868-018-0445-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090721/
https://www.ncbi.nlm.nih.gov/pubmed/30103703
http://dx.doi.org/10.1186/s12868-018-0445-9

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