E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer

The aim of this study was to uncover the pathogenic relevance and the underlying molecular mechanism of a novel CDH1 variant found in a Hereditary Diffuse Gastric Cancer family (p.L13_L15del), which affects the signal peptide of E-cadherin without changing the remaining predicted sequence. We verifi...

Descripción completa

Detalles Bibliográficos
Autores principales: Figueiredo, Joana, Melo, Soraia, Gamet, Kimberley, Godwin, Tanis, Seixas, Susana, Sanches, João M., Guilford, Parry, Seruca, Raquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090902/
https://www.ncbi.nlm.nih.gov/pubmed/30068367
http://dx.doi.org/10.1186/s12943-018-0859-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090902/
https://www.ncbi.nlm.nih.gov/pubmed/30068367
http://dx.doi.org/10.1186/s12943-018-0859-0

Ejemplares similares