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E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer

The aim of this study was to uncover the pathogenic relevance and the underlying molecular mechanism of a novel CDH1 variant found in a Hereditary Diffuse Gastric Cancer family (p.L13_L15del), which affects the signal peptide of E-cadherin without changing the remaining predicted sequence. We verifi...

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Detalles Bibliográficos
Autores principales:	Figueiredo, Joana, Melo, Soraia, Gamet, Kimberley, Godwin, Tanis, Seixas, Susana, Sanches, João M., Guilford, Parry, Seruca, Raquel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Letter to the Editor
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090902/ https://www.ncbi.nlm.nih.gov/pubmed/30068367 http://dx.doi.org/10.1186/s12943-018-0859-0

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