Cargando…

MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling

BACKGROUND: Chemotherapeutic agents that modulate cell cycle checkpoints and/or tumor-specific pathways have shown immense promise in preclinical and clinical studies aimed at anti-cancer therapy. MASTL (Greatwall in Xenopus and Drosophila), a serine/threonine kinase controls the final G2/M checkpoi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Uppada, Srijayaprakash Babu, Gowrikumar, Saiprasad, Ahmad, Rizwan, Kumar, Balawant, Szeglin, Bryan, Chen, Xi, Smith, J. Joshua, Batra, Surinder K., Singh, Amar B., Dhawan, Punita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090950/ https://www.ncbi.nlm.nih.gov/pubmed/30068336 http://dx.doi.org/10.1186/s12943-018-0848-3

Ejemplares similares

Upregulated Claudin-1 Expression Promotes Colitis-associated Cancer by promoting β-Catenin phosphorylation and activation in Notch/p-AKT Dependent Manner
por: Gowrikumar, Saiprasad, et al.
Publicado: (2019)

Role of Claudin Proteins in Regulating Cancer Stem Cells and Chemoresistance-Potential Implication in Disease Prognosis and Therapy
por: Gowrikumar, Saiprasad, et al.
Publicado: (2019)

Loss of Claudin-3 Expression Induces IL6/gp130/Stat3 Signaling to Promote Colon Cancer Malignancy by Hyperactivating Wnt/β-Catenin signaling
por: Ahmad, Rizwan, et al.
Publicado: (2017)

A Claudin-Based Molecular Signature Identifies High-Risk, Chemoresistant Colorectal Cancer Patients
por: Gowrikumar, Saiprasad, et al.
Publicado: (2021)

PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells
por: Kumar, Balawant, et al.
Publicado: (2021)

MASTL: A novel therapeutic target for Cancer Malignancy
por: Fatima, Iram, et al.
Publicado: (2020)

HDAC-4 regulates claudin-2 expression in EGFR-ERK1/2 dependent manner to regulate colonic epithelial cell differentiation
por: Ahmad, Rizwan, et al.
Publicado: (2017)

Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling
por: Lama Tamang, Raju, et al.
Publicado: (2023)

Colonoscopy-based intramucosal transplantation of cancer cells for mouse modeling of colon cancer and lung metastasis
por: Ahmad, Rizwan, et al.
Publicado: (2021)

P62/SQSTM1 binds with claudin-2 to target for selective autophagy in stressed intestinal epithelium
por: Ahmad, Rizwan, et al.
Publicado: (2023)

Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting
por: Conway, James Ronald William, et al.
Publicado: (2020)

The Oncogenic Functions of MASTL Kinase
por: Marzec, Kamila, et al.
Publicado: (2018)

Cocaine Induces Inflammatory Gut Milieu by Compromising the Mucosal Barrier Integrity and Altering the Gut Microbiota Colonization
por: Chivero, Ernest T., et al.
Publicado: (2019)

MUC4 is negatively regulated through the Wnt/β-catenin pathway via the Notch effector Hath1 in colorectal cancer
por: Pai, Priya, et al.
Publicado: (2016)

Caudal Homeobox Protein Cdx-2 Cooperates with Wnt Pathway to Regulate Claudin-1 Expression in Colon Cancer Cells
por: Bhat, Ajaz A., et al.
Publicado: (2012)

Discovery and Characterization of a Novel MASTL Inhibitor MKI-2 Targeting MASTL-PP2A in Breast Cancer Cells and Oocytes
por: Kang, Minsung, et al.
Publicado: (2021)

Cancer Stem Cell and Gastrointestinal Cancer: Current Status, Targeted Therapy and Future Implications
por: Ahmad, Rizwan, et al.
Publicado: (2016)

Role of Wnt/β-Catenin Signaling in the Chemoresistance Modulation of Colorectal Cancer
por: Yuan, Shengli, et al.
Publicado: (2020)

SILAC kinase screen identifies potential MASTL substrates
por: Marzec, Kamila A., et al.
Publicado: (2022)

Claudin-2 inhibits renal clear cell carcinoma progression by inhibiting YAP-activation
por: Kumar, Balawant, et al.
Publicado: (2021)

Claudin-1 overexpression in intestinal epithelial cells enhances susceptibility to adenamatous polyposis coli-mediated colon tumorigenesis
por: Pope, Jillian L, et al.
Publicado: (2014)

Melatonin reverses nasopharyngeal carcinoma cisplatin chemoresistance by inhibiting the Wnt/β-catenin signaling pathway
por: Zhang, Jian, et al.
Publicado: (2020)

MASTL overexpression promotes chromosome instability and metastasis in breast cancer
por: Rogers, Samuel, et al.
Publicado: (2018)

Caveolin-1 Promotes Chemoresistance of Gastric Cancer Cells to Cisplatin by Activating WNT/β-Catenin Pathway
por: Wang, Xi, et al.
Publicado: (2020)

Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance
por: Wickström, Malin, et al.
Publicado: (2015)

Claudin-2 protects against colitis-associated cancer by promoting colitis-associated mucosal healing
por: Ahmad, Rizwan, et al.
Publicado: (2023)

Mastl/PP2A regulate Cdk1 in ooycte maturation
por: Adhikari, Deepak, et al.
Publicado: (2015)

Mastl kinase, a promising therapeutic target, promotes cancer recurrence
por: Wang, Ling, et al.
Publicado: (2014)

MASTL promotes cell contractility and motility through kinase-independent signaling
por: Taskinen, Maria Emilia, et al.
Publicado: (2020)

Obesity-induces Organ and Tissue Specific Tight Junction Restructuring and Barrier Deregulation by Claudin Switching
por: Ahmad, Rizwan, et al.
Publicado: (2017)

Role of Wnt/β-catenin, Wnt/c-Jun N-terminal kinase and Wnt/Ca(2+) pathways in cisplatin-induced chemoresistance in ovarian cancer
por: Huang, Lu, et al.
Publicado: (2016)

Involvement of Wnt/β-catenin signaling in the mesenchymal stem cells promote metastatic growth and chemoresistance of cholangiocarcinoma
por: Wang, Weiwei, et al.
Publicado: (2015)

circ_0003418 Inhibits Tumorigenesis And Cisplatin Chemoresistance Through Wnt/β-Catenin Pathway In Hepatocellular Carcinoma
por: Chen, Hang, et al.
Publicado: (2019)

PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells
por: Rogers, Samuel, et al.
Publicado: (2016)

Inflammatory cytokine-induced expression of MASTL is involved in hepatocarcinogenesis by regulating cell cycle progression
por: Cao, Liye, et al.
Publicado: (2019)

The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery
por: Li, Yanqiu, et al.
Publicado: (2023)

The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery
por: Li, Yanqiu, et al.
Publicado: (2023)

Silencing LGR6 Attenuates Stemness and Chemoresistance via Inhibiting Wnt/β-Catenin Signaling in Ovarian Cancer
por: Ruan, Xiaohong, et al.
Publicado: (2019)

Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway
por: Liu, Xiaofeng, et al.
Publicado: (2021)

MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels
por: Närvä, Elisa, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gp06nka8mu82fs3573g0d5dpqr