NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

BACKGROUND: Activation of the NLRP3 inflammasome in gout amplifies the inflammatory response and mediates further damage. In the current study, we assessed the therapeutic effect of OLT1177, an orally active NLRP3 inflammasome inhibitor that is safe in humans, in murine acute arthritis models. METHO...

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Detalles Bibliográficos
Autores principales: Marchetti, Carlo, Swartzwelter, Benjamin, Koenders, Marije I., Azam, Tania, Tengesdal, Isak W., Powers, Nick, de Graaf, Dennis M., Dinarello, Charles A., Joosten, Leo A. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091035/
https://www.ncbi.nlm.nih.gov/pubmed/30075804
http://dx.doi.org/10.1186/s13075-018-1664-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091035/
https://www.ncbi.nlm.nih.gov/pubmed/30075804
http://dx.doi.org/10.1186/s13075-018-1664-2

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