Cargando…

NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

BACKGROUND: Activation of the NLRP3 inflammasome in gout amplifies the inflammatory response and mediates further damage. In the current study, we assessed the therapeutic effect of OLT1177, an orally active NLRP3 inflammasome inhibitor that is safe in humans, in murine acute arthritis models. METHO...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marchetti, Carlo, Swartzwelter, Benjamin, Koenders, Marije I., Azam, Tania, Tengesdal, Isak W., Powers, Nick, de Graaf, Dennis M., Dinarello, Charles A., Joosten, Leo A. B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091035/ https://www.ncbi.nlm.nih.gov/pubmed/30075804 http://dx.doi.org/10.1186/s13075-018-1664-2

Ejemplares similares

Dexamethasone and OLT1177 Cooperate in the Reduction of Melanoma Growth by Inhibiting STAT3 Functions
por: Dinarello, Alberto, et al.
Publicado: (2023)

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
por: Marchetti, Carlo, et al.
Publicado: (2018)

The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer’s disease
por: Lonnemann, Niklas, et al.
Publicado: (2020)

OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis
por: Sánchez-Fernández, Alba, et al.
Publicado: (2019)

Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers
por: Tengesdal, Isak W., et al.
Publicado: (2022)

Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression
por: Tengesdal, Isak W., et al.
Publicado: (2021)

Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177(®) (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction
por: Aliaga, Joseph, et al.
Publicado: (2021)

IL-38 Gene Deletion Worsens Murine Colitis
por: de Graaf, Dennis M., et al.
Publicado: (2022)

The Olt.
Publicado: (1964)

Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion
por: Tengesdal, Isak W., et al.
Publicado: (2021)

Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3
por: Oosting, Marije, et al.
Publicado: (2012)

Retraction to 10.1177/1758835920922055
Publicado: (2023)

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii
por: Gorfu, Gezahegn, et al.
Publicado: (2014)

NLRP3 Inflammasome: Key Mediator of Neuroinflammation in Murine Japanese Encephalitis
por: Kaushik, Deepak Kumar, et al.
Publicado: (2012)

Volcanic Ash Activates the NLRP3 Inflammasome in Murine and Human Macrophages
por: Damby, David E., et al.
Publicado: (2018)

Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma
por: Zhai, Zili, et al.
Publicado: (2020)

The NLRP6 inflammasome
por: Zheng, Danping, et al.
Publicado: (2020)

NLRP3 inflammasome activation in murine macrophages caused by Neospora caninum infection
por: Wang, Xiaocen, et al.
Publicado: (2017)

Role of Annexin A1 in NLRP3 Inflammasome Activation in Murine Neutrophils
por: Sanches, José Marcos, et al.
Publicado: (2021)

Predictors of renal recovery in patients with pre-orthotopic liver transplant (OLT) renal dysfunction
por: Iglesias, Jose, et al.
Publicado: (2013)

Agrometeorological drought in the Romanian plain within the sector delimited by the valleys of the Olt and Buzău Rivers
por: Murărescu, Ovidiu, et al.
Publicado: (2014)

1317. Pharmacokinetics (PK) of Ampicillin-Sulbactam (SAM) during Orthotopic Liver Transplantation (OLT)
por: Lasko, Maxwell J, et al.
Publicado: (2020)

Accumulation and ecotoxicological risk assessment of heavy metals in surface sediments of the Olt River, Romania
por: Iordache, Andreea Maria, et al.
Publicado: (2022)

NLRP3 inflammasome activation in neutrophils directs early inflammatory response in murine peritonitis
por: Fukui, Saeko, et al.
Publicado: (2022)

Location of the Ankle Osteochondral Lesion of the Talus (OLT) Corresponding to the Anatomical Axis of the Tibia (Loading Axis) Crosses the Ankle Joint
por: Sandberg, Maxwell L., et al.
Publicado: (2022)

Evidence That a TRPA1-Mediated Murine Model of Temporomandibular Joint Pain Involves NLRP3 Inflammasome Activation
por: Kodji, Xenia, et al.
Publicado: (2021)

Inhibiting the NLRP3 Inflammasome
por: El-Sharkawy, Lina Y., et al.
Publicado: (2020)

Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment
por: Amo-Aparicio, Jesus, et al.
Publicado: (2023)

NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma
por: Zhai, Zili, et al.
Publicado: (2017)

Successful Pregnancies in Two Orthotopic Liver Transplant (OLT) Recipients in Iran; Two Case Reports
por: Tayebi, Zahra, et al.
Publicado: (2009)

Nonessential Role for the NLRP1 Inflammasome Complex in a Murine Model of Traumatic Brain Injury
por: Brickler, Thomas, et al.
Publicado: (2016)

Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model
por: Carlos, Daniela, et al.
Publicado: (2017)

Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria
por: González‐Dominguez, Alvaro, et al.
Publicado: (2021)

A study of 1177 odontogenic lesions in a South Kerala population
por: Deepthi, PV, et al.
Publicado: (2016)

Research Progress of Mitochondrial Mechanism in NLRP3 Inflammasome Activation and Exercise Regulation of NLRP3 Inflammasome
por: Zhang, Tan, et al.
Publicado: (2021)

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease
por: Saresella, Marina, et al.
Publicado: (2016)

The Role of Inflammasome-Dependent and Inflammasome-Independent NLRP3 in the Kidney
por: Kim, Yang Gyun, et al.
Publicado: (2019)

Activation of the NLRP3 Inflammasome Pathway by Uropathogenic Escherichia coli Is Virulence Factor-Dependent and Influences Colonization of Bladder Epithelial Cells
por: Demirel, Isak, et al.
Publicado: (2018)

The role of the NLRP3 inflammasome in gout
por: Kingsbury, Sarah R, et al.
Publicado: (2011)

The Role of the NLRP3 Inflammasome in Fibrosis
por: Artlett, Carol M
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_mvl5dbq5olnsjplg957uigegjj