Evolutionary stability of topologically associating domains is associated with conserved gene regulation

BACKGROUND: The human genome is highly organized in the three-dimensional nucleus. Chromosomes fold locally into topologically associating domains (TADs) defined by increased intra-domain chromatin contacts. TADs contribute to gene regulation by restricting chromatin interactions of regulatory seque...

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Detalles Bibliográficos
Autores principales: Krefting, Jan, Andrade-Navarro, Miguel A., Ibn-Salem, Jonas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091198/
https://www.ncbi.nlm.nih.gov/pubmed/30086749
http://dx.doi.org/10.1186/s12915-018-0556-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091198/
https://www.ncbi.nlm.nih.gov/pubmed/30086749
http://dx.doi.org/10.1186/s12915-018-0556-x

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