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Evolutionary stability of topologically associating domains is associated with conserved gene regulation
BACKGROUND: The human genome is highly organized in the three-dimensional nucleus. Chromosomes fold locally into topologically associating domains (TADs) defined by increased intra-domain chromatin contacts. TADs contribute to gene regulation by restricting chromatin interactions of regulatory seque...
Autores principales: | Krefting, Jan, Andrade-Navarro, Miguel A., Ibn-Salem, Jonas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091198/ https://www.ncbi.nlm.nih.gov/pubmed/30086749 http://dx.doi.org/10.1186/s12915-018-0556-x |
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