Primary Deuterium Kinetic Isotope Effects: A Probe for the Origin of the Rate Acceleration for Hydride Transfer Catalyzed by Glycerol-3-Phosphate Dehydrogenase

[Image: see text] Large primary deuterium kinetic isotope effects (1° DKIEs) on enzyme-catalyzed hydride transfer may be observed when the transferred hydride tunnels through the energy barrier. The following 1° DKIEs on k(cat)/K(m) and relative reaction driving force are reported for wild-type and...

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Detalles Bibliográficos
Autores principales: Reyes, Archie C., Amyes, Tina L., Richard, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091503/
https://www.ncbi.nlm.nih.gov/pubmed/29927590
http://dx.doi.org/10.1021/acs.biochem.8b00536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091503/
https://www.ncbi.nlm.nih.gov/pubmed/29927590
http://dx.doi.org/10.1021/acs.biochem.8b00536

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