Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice

OBJECTIVE—: The E3 ubiquitin ligase IDOL (inducible degrader of the LDLR [LDL (low-density lipoprotein) receptor]) is a post-transcriptional regulator of LDLR abundance. Model systems and human genetics support a role for IDOL in regulating circulating LDL levels. Whether IDOL plays a broader metabo...

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Detalles Bibliográficos
Autores principales: van Loon, Nienke M., Ottenhoff, Roelof, Kooijman, Sander, Moeton, Martina, Scheij, Saskia, Roscam Abbing, Reinout L.P., Gijbels, Marion J.J., Levels, Johannes H.M., Sorrentino, Vincenzo, Berbée, Jimmy F.P., Rensen, Patrick C.N., Zelcer, Noam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Basic Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092113/
https://www.ncbi.nlm.nih.gov/pubmed/29903737
http://dx.doi.org/10.1161/ATVBAHA.118.311168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092113/
https://www.ncbi.nlm.nih.gov/pubmed/29903737
http://dx.doi.org/10.1161/ATVBAHA.118.311168

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