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Engineering of Primary Human B cells with CRISPR/Cas9 Targeted Nuclease
B cells offer unique opportunities for gene therapy because of their ability to secrete large amounts of protein in the form of antibody and persist for the life of the organism as plasma cells. Here, we report optimized CRISPR/Cas9 based genome engineering of primary human B cells. Our procedure in...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092381/ https://www.ncbi.nlm.nih.gov/pubmed/30108345 http://dx.doi.org/10.1038/s41598-018-30358-0 |