Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes

Tumors deficient in the urea cycle enzymes argininosuccinate synthase-1 (ASS1) and ornithine transcarbamylase (OTC) are unable to synthesize arginine and can be targeted using arginine-deprivation therapy. Here, we show that colorectal cancers (CRCs) display negligible expression of OTC and, in subs...

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Detalles Bibliográficos
Autores principales: Alexandrou, Constantinos, Al-Aqbi, Saif Sattar, Higgins, Jennifer A., Boyle, William, Karmokar, Ankur, Andreadi, Catherine, Luo, Jin-Li, Moore, David A., Viskaduraki, Maria, Blades, Matthew, Murray, Graeme I., Howells, Lynne M., Thomas, Anne, Brown, Karen, Cheng, Paul N., Rufini, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092409/
https://www.ncbi.nlm.nih.gov/pubmed/30108309
http://dx.doi.org/10.1038/s41598-018-30591-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092409/
https://www.ncbi.nlm.nih.gov/pubmed/30108309
http://dx.doi.org/10.1038/s41598-018-30591-7

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