Automated fluorescence intensity and gradient analysis enables detection of rare fluorescent mutant cells deep within the tissue of RaDR mice

Homologous recombination (HR) events are key drivers of cancer-promoting mutations, and the ability to visualize these events in situ provides important information regarding mutant cell type, location, and clonal expansion. We have previously created the Rosa26 Direct Repeat (RaDR) mouse model wher...

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Detalles Bibliográficos
Autores principales: Wadduwage, Dushan N., Kay, Jennifer, Singh, Vijay Raj, Kiraly, Orsolya, Sukup-Jackson, Michelle R., Rajapakse, Jagath, Engelward, Bevin P., So, Peter T. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092416/
https://www.ncbi.nlm.nih.gov/pubmed/30108260
http://dx.doi.org/10.1038/s41598-018-30557-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092416/
https://www.ncbi.nlm.nih.gov/pubmed/30108260
http://dx.doi.org/10.1038/s41598-018-30557-9

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