Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer’s disease

Alzheimer’s disease (AD) represents a major healthcare burden with no effective treatment. The glutamate modulator, riluzole, was shown to reverse many AD-related gene expression changes and improve cognition in aged rats. However, riluzole’s effect on amyloid beta (Aβ) pathology, a major histopatho...

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Detalles Bibliográficos
Autores principales: Okamoto, Masahiro, Gray, Jason D., Larson, Chloe S., Kazim, Syed Faraz, Soya, Hideaki, McEwen, Bruce S., Pereira, Ana C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092426/
https://www.ncbi.nlm.nih.gov/pubmed/30108205
http://dx.doi.org/10.1038/s41398-018-0201-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092426/
https://www.ncbi.nlm.nih.gov/pubmed/30108205
http://dx.doi.org/10.1038/s41398-018-0201-z

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