Detection of KIT mutations in core binding factor acute myeloid leukemia

We have investigated the frequency and the effect of KIT mutations on the outcome of patients with CBF-AML. 69 patients (34 pediatrics and 35 adults) with CBF-AML were enrolled in the study. The frequency of KIT mutations was higher in adults compared to pediatrics (22.9% and 14.7%, p = 0.38) respec...

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Autores principales: Badr, Passant, Elsayed, Ghada M, Eldin, Dalia Negm, Riad, Bahia Y, Hamdy, Nayera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092444/
https://www.ncbi.nlm.nih.gov/pubmed/30112273
http://dx.doi.org/10.1016/j.lrr.2018.06.004
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author Badr, Passant
Elsayed, Ghada M
Eldin, Dalia Negm
Riad, Bahia Y
Hamdy, Nayera
author_facet Badr, Passant
Elsayed, Ghada M
Eldin, Dalia Negm
Riad, Bahia Y
Hamdy, Nayera
author_sort Badr, Passant
collection PubMed
description We have investigated the frequency and the effect of KIT mutations on the outcome of patients with CBF-AML. 69 patients (34 pediatrics and 35 adults) with CBF-AML were enrolled in the study. The frequency of KIT mutations was higher in adults compared to pediatrics (22.9% and 14.7%, p = 0.38) respectively. Leukocytosis ≥ 20 × 10(9) /L was significantly associated with pediatrics compared to adults. t(8;21)(q22;22) was significantly associated with thrombocytopenia in adults. We conclude that no significant difference is found between KIT mutated and unmutated CBF-AML in adults and pediatrics. Children with CBF-AML present with leukocytosis. t(8;21) is associated with thrombocytopenia.
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spelling pubmed-60924442018-08-15 Detection of KIT mutations in core binding factor acute myeloid leukemia Badr, Passant Elsayed, Ghada M Eldin, Dalia Negm Riad, Bahia Y Hamdy, Nayera Leuk Res Rep Article We have investigated the frequency and the effect of KIT mutations on the outcome of patients with CBF-AML. 69 patients (34 pediatrics and 35 adults) with CBF-AML were enrolled in the study. The frequency of KIT mutations was higher in adults compared to pediatrics (22.9% and 14.7%, p = 0.38) respectively. Leukocytosis ≥ 20 × 10(9) /L was significantly associated with pediatrics compared to adults. t(8;21)(q22;22) was significantly associated with thrombocytopenia in adults. We conclude that no significant difference is found between KIT mutated and unmutated CBF-AML in adults and pediatrics. Children with CBF-AML present with leukocytosis. t(8;21) is associated with thrombocytopenia. Elsevier 2018-07-21 /pmc/articles/PMC6092444/ /pubmed/30112273 http://dx.doi.org/10.1016/j.lrr.2018.06.004 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Badr, Passant
Elsayed, Ghada M
Eldin, Dalia Negm
Riad, Bahia Y
Hamdy, Nayera
Detection of KIT mutations in core binding factor acute myeloid leukemia
title Detection of KIT mutations in core binding factor acute myeloid leukemia
title_full Detection of KIT mutations in core binding factor acute myeloid leukemia
title_fullStr Detection of KIT mutations in core binding factor acute myeloid leukemia
title_full_unstemmed Detection of KIT mutations in core binding factor acute myeloid leukemia
title_short Detection of KIT mutations in core binding factor acute myeloid leukemia
title_sort detection of kit mutations in core binding factor acute myeloid leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092444/
https://www.ncbi.nlm.nih.gov/pubmed/30112273
http://dx.doi.org/10.1016/j.lrr.2018.06.004
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AT riadbahiay detectionofkitmutationsincorebindingfactoracutemyeloidleukemia
AT hamdynayera detectionofkitmutationsincorebindingfactoracutemyeloidleukemia

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