An Augmented Negative Force-Frequency Relationship and Slowed Mechanical Restitution Are Associated With Increased Susceptibility to Drug-Induced Torsade de Pointes Arrhythmias in the Chronic Atrioventricular Block Dog

Introduction: In the chronic AV-block (CAVB) dog model, structural, contractile, and electrical remodeling occur, which predispose the heart to dofetilide-induced Torsade de Pointes (TdP) arrhythmias. Previous studies found a relation between electrical remodeling and inducibility of TdP, while stru...

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Detalles Bibliográficos
Autores principales: Sprenkeler, David J., Bossu, Alexandre, Beekman, Jet D. M., Schoenmakers, Marieke, Vos, Marc A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092493/
https://www.ncbi.nlm.nih.gov/pubmed/30135660
http://dx.doi.org/10.3389/fphys.2018.01086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092493/
https://www.ncbi.nlm.nih.gov/pubmed/30135660
http://dx.doi.org/10.3389/fphys.2018.01086

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