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An Augmented Negative Force-Frequency Relationship and Slowed Mechanical Restitution Are Associated With Increased Susceptibility to Drug-Induced Torsade de Pointes Arrhythmias in the Chronic Atrioventricular Block Dog

Introduction: In the chronic AV-block (CAVB) dog model, structural, contractile, and electrical remodeling occur, which predispose the heart to dofetilide-induced Torsade de Pointes (TdP) arrhythmias. Previous studies found a relation between electrical remodeling and inducibility of TdP, while stru...

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Detalles Bibliográficos
Autores principales:	Sprenkeler, David J., Bossu, Alexandre, Beekman, Jet D. M., Schoenmakers, Marieke, Vos, Marc A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092493/ https://www.ncbi.nlm.nih.gov/pubmed/30135660 http://dx.doi.org/10.3389/fphys.2018.01086

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