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RIM‐binding proteins recruit BK‐channels to presynaptic release sites adjacent to voltage‐gated Ca(2+)‐channels

The active zone of presynaptic nerve terminals organizes the neurotransmitter release machinery, thereby enabling fast Ca(2+)‐triggered synaptic vesicle exocytosis. BK‐channels are Ca(2+)‐activated large‐conductance K(+)‐channels that require close proximity to Ca(2+)‐channels for activation and con...

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Detalles Bibliográficos
Autores principales: Sclip, Alessandra, Acuna, Claudio, Luo, Fujun, Südhof, Thomas C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092624/
https://www.ncbi.nlm.nih.gov/pubmed/29967030
http://dx.doi.org/10.15252/embj.201798637