Rapamycin Upregulates Connective Tissue Growth Factor Expression in Hepatic Progenitor Cells Through TGF-β-Smad2 Dependent Signaling

Rapamycin (sirolimus) is a mTOR kinase inhibitor and is widely used as an immunosuppressive drug to prevent graft rejection in organ transplantation currently. However, some recent investigations have reported that it had profibrotic effect in the progression of organ fibrosis, and its precise role...

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Detalles Bibliográficos
Autores principales: Wu, Yu, Wang, Wei, Peng, Xiang-mei, He, Yi, Xiong, Yi-xiao, Liang, Hui-fang, Chu, Liang, Zhang, Bi-xiang, Ding, Ze-yang, Chen, Xiao-ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092675/
https://www.ncbi.nlm.nih.gov/pubmed/30135653
http://dx.doi.org/10.3389/fphar.2018.00877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092675/
https://www.ncbi.nlm.nih.gov/pubmed/30135653
http://dx.doi.org/10.3389/fphar.2018.00877

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