Cargando…
K(v)1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4(+) effector memory T cell response to TCR stimulation
BACKGROUND: In T cells, the K(v)1.3 and the K(Ca)3.1 potassium channels regulate the membrane potential and calcium homeostasis. Notably, during T(EM) cell activation, the number of K(v)1.3 channels on the cell membrane dramatically increases. K(v)1.3 blockade results in inhibition of Ca(2+) signali...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092819/ https://www.ncbi.nlm.nih.gov/pubmed/30107837 http://dx.doi.org/10.1186/s12964-018-0257-7 |