K(v)1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4(+) effector memory T cell response to TCR stimulation

BACKGROUND: In T cells, the K(v)1.3 and the K(Ca)3.1 potassium channels regulate the membrane potential and calcium homeostasis. Notably, during T(EM) cell activation, the number of K(v)1.3 channels on the cell membrane dramatically increases. K(v)1.3 blockade results in inhibition of Ca(2+) signali...

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Detalles Bibliográficos
Autores principales: Veytia-Bucheli, José Ignacio, Jiménez-Vargas, Juana María, Melchy-Pérez, Erika Isabel, Sandoval-Hernández, Monserrat Alba, Possani, Lourival Domingos, Rosenstein, Yvonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092819/
https://www.ncbi.nlm.nih.gov/pubmed/30107837
http://dx.doi.org/10.1186/s12964-018-0257-7

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